Male Organ Health: How to Perform Self-Examinations

Men generally don’t need to be told to spend time looking at and feeling their male organs; these are activities they tend to perform frequently and on a voluntary basis. However, it’s important to pay this type of attention to the male organ for purposes beyond the recreational. Self-examinations are how many men first become aware of symptoms that may indicate poor male organ health. Since early detection and treatment are ideal for most all health conditions, men should commit to performing regular examinations of the equipment with an eye toward abnormalities. Keep the following in mind when performing self-exams.

The Sack

Men should spend some time with their sacks to feel for any lumps, painful areas or surface bumps. The ideal time to examine the sack is when a man has just emerged from a warm shower, as the boys will be descended.

Go one at a time. Take a ball in the fingers and gently roll it around. If a man has a painful or tender area, this could indicate an infection. If he feels a hard area or lump, no matter how small, this could be the first sign of cancer. In either case, a man should seek medical attention to confirm or rule out a health problem.

Men should also look and feel for surface bumps that may indicate a rash or sensually transmitted infection. Different rashes and infections manifest in different ways. Anything abnormal is reason to seek out diagnosis from a medical professional.

The Male Organ

There are a number of things to look and feel for along the male organ:

• Bumps, sores or warts: Beginning with the head (and under the sheath if uncut), a man should slowly and carefully examine for these symptoms. Move to the shaft next, being mindful not to neglect the hard-to-see underside (a mirror can help here). Once a man has felt and visually examined the head and shaft, move on to the base. Separate groin hair and examine the skin beneath it for bumps, sores or warts.

• Urethral symptoms: Men should pay attention to how the opening of their male organs feel, and to what comes out of them. Does it burn when one urinates? Is there abnormal discharge coming from the tip? These may indicate infections that require treatment.

• Sensitivity levels: A man should also reflect on his sensitivity levels. If he notices that he requires a tighter grip in order to feel pleasure when self-gratifying, for example, or has a hard time staying hard with a partner, these could indicate decreased member sensitivity. Resolving the issue may involve treating an underlying nerve or circulation problem, or simply changing his self-pleasuring habits to reacquaint his male organ to gentler stimulation.

• Skin condition: How’s the skin look and feel? Is it smooth and supple or dry and flaky? Keeping the skin in good condition is important both for aesthetic and health reasons – chronically chafed skin can lead to reduced sensitivity levels over time.

Things that generally are not causes for concern are: a slight curve when hard; variation in color along the male organ (unless sudden); Fordyce spots; pearly papules.

If a man notices that his skin could be in better condition down there, he can begin using a skin care product made just for men. A quality male organ health crème (health professionals recommend Man1 Man Oil) will effectively manage common skin issues such as dryness and flakiness that may be caused by the frictions of the day and night. Man1 Man Oil contains Shea butter and vitamin E, two exceptional natural moisturizers. Taking a little time each day to apply the crème gives men the opportunity to feel around while contributing to the health of their members.

Visit http://www.menshealthfirst.com for additional information on most common male organ health issues, tips on improving organ sensitivity and what to do to maintain a healthy member. John Dugan is a professional writer who specializes in men’s health issues and is an ongoing contributing writer to numerous websites.

PNB Housing Finance Q2 results: Net profit dips 15% to Rs 312 crore

PNB Housing Finance NSE 2.25 % reported a 15 percent dip in net profit on lower business volume and deterioration in asset quality while the company is still in limbo about raising growth capital.

Net profit for the mortgage lender stood at Rs 312 crore in the September quarter against Rs 367 crore in the year-ago period. Pre provision operating Profit remained stable at Rs 575 crore compared to Rs 578 crore over the same period.

The company’s net interest margin stood at 3.5 percent as compared to 3.2 percent a year back.

Its loan disbursements nearly halved at Rs 2,444 crore in the second quarter compared with Rs 4,969 crore in the year-ago period. Its asset under management (AUM) shrunk to Rs 81,221 crore from Rs 89,471 crore.

The company said its loan disbursements during the quarter witnessed gradual pick up, primarily in the retail segment, and has reached 86 percent of pre-Covid-19 levels. Retail loans contribute 82 percent of the AUM.

Its gross NPA stood at 2.59 percent of loan assets while net NPA stood at 1.46 percent against 0.65 percent a year back.

The board of PNB Housing Finance has already approved to raise Rs 1800 crore through rights issue or preferential issue to augment its capital base. The decision will be subject to requisite approvals including those from shareholders through a general body meeting or postal ballots, the company said in the exchange filing. Its shares had climbed over 10% as investors anticipated the fundraise. Its promoter Punjab National Bank NSE 0.56 % is awaiting the regulator’s approval to pump in up to Rs 600 crore in the company, which has been looking to mobilize capital for over three quarters now.

ACE Digital Platform

“Demand for Housing Loan to improve,” said Hardayal Prasad, MD, CEO of the company. PNB Housing Finance is set to launch the housing finance industry’s first digital platform for loans offering. With the launch of its ACE digital platform, the company intends to leverage the technology to offer a convenient and contactless loan process for its customers.

The new digital platform automates the end-to-end loan process, including data collection and verification as well as lead generation and management through various digital channels.

Using this new platform, the customers can upload documents online leading to a backward integration of the verification process such as PAN, Aadhaar, digital signatures, and video-based KYC and geo-tagging. The information is then integrated into the company’s underwriting platform for further processing of the loan application.

For FY21, the company has set a target of 9-10% of new loans through its ACE digital platform as the pandemic will also motivate prospective customers to use this new digital channel for the loans they need. NSE india limited Shares

A Novel Protein That Promotes Cancer Progression Revealed

Cancer occurs when the genetic code of normal cells is changed, causing excessive growth. Researchers at the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) have discovered a protein that drives the growth of esophageal or liver cancer by altering the genetic code in a novel way.

This protein called death associated protein 3 (DAP3) inhibits a process called adenosine-inosine (A-to-I) RNA editing, which usually corrects the genetic code to ensure the correct expression of genes. By inhibiting RNA editing, DAP3 becomes an oncogene— a gene that has the potential to cause cancer. The findings provide potential for the development of new drugs for cancer treatment against DAP3.

The study, led by Polly Chen, lead researcher and assistant professor at CSI in Singapore, was recently published in the scientific journal Science Advances.

RNA is the most important class of molecules in cells. They not only convert genetic information stored in DNA into proteins, but also play important regulatory roles in various biological processes. RNA editing is a process in which RNA produced by DNA transcription is altered, resulting in altered proteins. In humans, the most common type of RNA editing is A-to-I editing, mediated by ADAR proteins (ADAR1 and ADAR2). Over the past decade, many studies have reported that the accumulation of deleterious changes in A-to-IRNA editing can trigger cells to develop cancer. However, current knowledge on how the A-to-I RNA editing process is regulated in cancer remains limited.

Therefore, the CSI Singapore research team carried out a study to understand how DAP3, an interacting protein of A-to-I RNA-editing catalytic enzymes (ADAR1 and ADAR2), regulates the process in cancer cells.

The team demonstrated that DAP3 can disrupt the binding of ADAR2 protein to target RNA, thereby inhibiting the editing of A-to-I RNA in cancer cells. This inhibition may be one of the pathways by which DAP3 promotes tumor development.

Their analysis also showed that DAP3 expression was elevated in 17 cancers. Further experiments showed that DAP3 acts as an oncogene in esophageal cancer and liver cancer cells. Interestingly, they also found that one of the editing targets inhibited by DAP3 was the PDZD7 gene, and found that altering the editing of PDZD7 generated new PDZD7 protein products that promoted DAP3-driven tumor growth.

Collectively, these observations reveal the complexity of the A-to-I RNA editing process in cancer cells and suggest that DAP3 may be a promising target for future cancer drug development.

“With this new knowledge, we can now study how to intervene in the interaction between DAP3 and ADAR proteins to intervene in RNA-editing-mediated cancer promotion processes in cells,” said Professor Chen, a research leader Asst.